Our research in magnetic resonance spans a very broad range. We have collaborated with leading groups in the development of novel MRI hardware, such as the world’s first 128-channel cardiac MRI coil. We have a major interest in the development and application of new contrast mechanisms in magnetic resonance such as off-resonance imaging, ultrashort-echo time imaging, chemical exchange saturation transfer and diffusion MRI of the heart. The use of diffusion MRI to characterize the microstructure of the heart is a particular interest. We have played a leading role in the development of techniques to image the diffusion of water in the heart and in the development of novel parameters to characterize the cellular architecture of the heart.

Selected Papers

Nguyen CT, Dawkins J, Bi X, Marban E and Li D. Diffusion Tensor Cardiac Magnetic Resonance Reveals Exosomes From Cardiosphere-Derived Cells Preserve Myocardial Fiber Architecture After Myocardial Infarction. JACC Basic Transl Sci. 2018;3:97-109.

Mekkaoui C, Jackowski MP, Kostis WJ, Stoeck CT, Thiagalingam A, Reese TG, Reddy VY, Ruskin JN, Kozerke S and Sosnovik DE. Myocardial Scar Delineation Using Diffusion Tensor Magnetic Resonance Tractography. J Am Heart Assoc. 2018;7:e007834.

Mekkaoui C, Reese TG, Jackowski MP, Cauley SF, Setsompop K, Bhat H and Sosnovik DE. Diffusion Tractography of the Entire Left Ventricle by Using Free-breathing Accelerated Simultaneous Multisection Imaging. Radiology. 2017;282:850-856.

Sosnovik DE, Mekkaoui C, Huang S, Chen HH, Dai G, Stoeck CT, Ngoy S, Guan J, Wang R, Kostis WJ, Jackowski MP, Wedeen VJ, Kozerke S and Liao R. Microstructural impact of ischemia and bone marrow-derived cell therapy revealed with diffusion tensor magnetic resonance imaging tractography of the heart in vivo. Circulation. 2014;129:1731-41.

Sosnovik DE, Wang R, Dai G, Wang T, Aikawa E, Novikov M, Rosenzweig A, Gilbert RJ and Wedeen VJ. Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium. Circ Cardiovasc Imaging. 2009;2:206-12.