Systems Modeling and Simulation
We have developed models of processes and phenomena such as cardiac situs, cell death and cardiomyocyte microstructure in the heart. We have a strong interest in the modeling of electrical conduction in the heart and how this can be used to better understand and prevent cardiac arrhythmias. Kinetic modeling of in vivo molecular imaging readouts is a significant focus and provides an important bridge between clinical human data and investigation in single cells.
Shah R, Ziegler O, Yeri A, Liu X, Murthy V, Rabideau D, Xiao CY, Hanspers K, Belcher A, Tackett M, Rosenzweig A, Pico AR, Januzzi JL and Das S. MicroRNAs Associated With Reverse Left Ventricular Remodeling in Humans Identify Pathways of Heart Failure Progression. Circ Heart Fail. 2018;11:e004278.
Kurz FT, Aon MA, O’Rourke B and Armoundas AA. Assessing Spatiotemporal and Functional Organization of Mitochondrial Networks. Methods Mol Biol. 2018;1782:383-402.
Yuan S, Zhao L, Brueckner M and Sun Z. Intraciliary calcium oscillations initiate vertebrate left-right asymmetry. Curr Biol. 2015;25:556-67.
Kurz FT, Derungs T, Aon MA, O’Rourke B and Armoundas AA. Mitochondrial networks in cardiac myocytes reveal dynamic coupling behavior. Biophys J. 2015;108:1922-33.
Kurz FT, Aon MA, O’Rourke B and Armoundas AA. Spatio-temporal oscillations of individual mitochondria in cardiac myocytes reveal modulation of synchronized mitochondrial clusters. Proc Natl Acad Sci U S A. 2010;107:14315-20.